«There are important consequences of sampling that have not been widely addressed. Some transcripts show abundances below one copy per cell, as a stable protein that is present at about one per cell in yeast, can be produced by a transcript expressed every few cell divisions (Ghaemmaghami et al, 2003)».
Sacado de «Synthetic spike-in standards for RNA-seq experiments» Jiang et al, 2011. Genome Research.
El banquete de Gargamelle 